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    Mechanisms of carrier formation during Clathrin-independent endocytosis

    Ferreira, A. and Boucrot, Emmanuel (2018) Mechanisms of carrier formation during Clathrin-independent endocytosis. Trends in Cell Biology 28 (3), pp. 188-200. ISSN 0962-8924.

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    Abstract

    Clathrin-independent endocytosis (CIE) mediates the cellular uptake of many extracellular ligands, receptors, and pathogens, including several life-threatening bacterial toxins and viruses. So far, our understanding of CIE carrier formation has lagged behind that of clathrin-coated vesicles. Impediments have been the imprecise definition of some CIE pathways, the lack of specific cargoes being transported and of exclusive cytosolic markers and regulators. Notwithstanding these limitations, three distinct molecular mechanisms by which CIE carriers form can be defined. Cargo capture by cytosolic proteins is the main mechanism used by fast endophilin-mediated endocytosis (FEME) and interleukin 2 receptor (IL-2R) endocytosis. Acute signaling-induced membrane remodeling drives macropinocytosis. Finally, extracellular lipid or cargo clustering by the glycolipid-lectin (GL-Lect) hypothesis mediates the uptake of Shiga and cholera toxins and receptors by the CLIC/GEEC pathway. Here, we review these mechanisms and highlight current gaps in knowledge that will need to be addressed to complete our understanding of CIE.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): clathrin-independent endocytosis, macropinocytosis, caveolae glycolipid-lectin (GL-Lect) hypothesis, glycosylphosphatidylinositol (GPI)-anchored proteins, clathrin-independent carriers/GPI-AP enriched endocytic compartments (CLIC/GEEC), fast endophilin-mediated endocytosis (FEME)
    School: School of Science > Biological Sciences
    Depositing User: Emmanuel Boucrot
    Date Deposited: 12 Mar 2018 09:42
    Last Modified: 26 Jun 2020 07:31
    URI: https://eprints.bbk.ac.uk/id/eprint/21457

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