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    Structural and molecular biology of Type IV Secretion Systems

    Terradot, L. and Bergé, C. and Waksman, Gabriel (2017) Structural and molecular biology of Type IV Secretion Systems. In: Backert, S. and Grohmann, E. (eds.) Type IV Secretion in Gram-Negative and Gram-Positive Bacteria. Current Topics in Microbiology and Immunology 413 413. Springer, pp. 31-60. ISBN 9783319752402.

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    Type IV secretion systems (T4SSs) are nanomachines that Gram-negative, Gram-positive bacteria, and some archaea use to transport macromolecules across their membranes into bacterial or eukaryotic host targets or into the extracellular milieu. They are the most versatile secretion systems, being able to deliver both proteins and nucleoprotein complexes into targeted cells. By mediating conjugation and/or competence, T4SSs play important roles in determining bacterial genome plasticity and diversity; they also play a pivotal role in the spread of antibiotic resistance within bacterial populations. T4SSs are also used by human pathogens such as Legionella pneumophila, Bordetella pertussis, Brucella sp., or Helicobacter pylori to sustain infection. Since they are essential virulence factors for these important pathogens, T4SSs might represent attractive targets for vaccines and therapeutics. The best-characterized conjugative T4SSs of Gram-negative bacteria are composed of twelve components that are conserved across many T4SSs. In this chapter, we will review our current structural knowledge on the T4SSs by describing the structures of the individual components and how they assemble into large macromolecular assemblies. With the combined efforts of X-ray crystallography, nuclear magnetic resonance (NMR), and more recently electron microscopy, structural biology of the T4SS has made spectacular progress during the past fifteen years and has unraveled the properties of unique proteins and complexes that assemble dynamically in a highly sophisticated manner.


    Item Type: Book Section
    Additional Information: Series ISSN: 0070-217X
    Keyword(s) / Subject(s): Bacterial pilus, Bacterial secretion system, Electron microscopy, Membrane transport, Nanomachine, Virulence factor, X-ray crystallography
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    SWORD Depositor: Mr Joe Tenant
    Depositing User: Mr Joe Tenant
    Date Deposited: 13 Apr 2018 08:34
    Last Modified: 02 Aug 2023 17:40


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