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    Emerging mechanisms of dynein transport in the cytoplasm versus the cilium

    Roberts, Anthony (2018) Emerging mechanisms of dynein transport in the cytoplasm versus the cilium. Biochemical Society Transactions , ISSN 0300-5127.

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    Two classes of dynein power long-distance cargo transport in different cellular contexts. Cytoplasmic dynein-1 is responsible for the majority of transport toward microtubule minus ends in the cell interior. Dynein-2, also known as intraflagellar transport dynein, moves cargoes along the axoneme of eukaryotic cilia and flagella. Both dyneins operate as large ATP-driven motor complexes, whose dysfunction is associated with a group of human disorders. But how similar are their mechanisms of action and regulation? To examine this question, this review focuses on recent advances in dynein-1 and -2 research, and probes to what extent the emerging principles of dynein-1 transport could apply to or differ from those of the less well-understood dynein-2 mechanoenzyme.


    Item Type: Article
    Keyword(s) / Subject(s): cilia, dynein, intraflagellar transport, kinesin, microtubule
    School: School of Science > Biological Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Anthony Roberts
    Date Deposited: 01 Aug 2018 13:52
    Last Modified: 04 Jul 2022 12:29


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