BIROn - Birkbeck Institutional Research Online

    The M-band: the underestimated part of the sarcomere

    Lange, S. and Pinotsis, Nikos and Agarkova, I. and Ehler, E. (2019) The M-band: the underestimated part of the sarcomere. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research , ISSN 0167-4889.

    [img]
    Preview
    Text
    26432.pdf - Published Version of Record
    Available under License Creative Commons Attribution.

    Download (3MB) | Preview

    Abstract

    The sarcomere is the basic unit of the myofibrils, which mediate skeletal and cardiac Muscle contraction. Two transverse structures, the Z-disc and the M-band, anchor the thin (actin and associated proteins) and thick (myosin and associated proteins) filaments to the elastic filament system composed of titin. A plethora of proteins are known to be integral or associated proteins of the Z-disc and its structural and signalling role in muscle is better understood, while the molecular constituents of the M-band and its function are less well defined. Evidence discussed here suggests that the M-band is important for managing force imbalances during active muscle contraction. Its molecular composition is fine-tuned, especially as far as the structural linkers encoded by members of the myomesin family are concerned and depends on the specific mechanical characteristics of each particular muscle fibre type. Muscle activity signals from the M-band to the nucleus and affects transcription of sarcomeric genes, especially via serum response factor (SRF). Due to its important role as shock absorber in contracting muscle, the M-band is also more and more recognised as a contributor to muscle disease. [Abstract copyright: Copyright © 2019. Published by Elsevier B.V.]

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Cardiomyopathy, Cytoskeleton, Myomesin, Obscurin, Sarcomere
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    SWORD Depositor: Mr Joe Tenant
    Depositing User: Mr Joe Tenant
    Date Deposited: 18 Mar 2019 09:33
    Last Modified: 02 Aug 2023 17:49
    URI: https://eprints.bbk.ac.uk/id/eprint/26432

    Statistics

    Activity Overview
    6 month trend
    0Downloads
    6 month trend
    0Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item
    Edit/View Item