BIROn - Birkbeck Institutional Research Online

    Decreased cingulo-opercular network functional connectivity mediates the impact of aging on visual processing speed

    Ruiz-Rizzo, A.L. and Sorg, C. and Napiórkowski, N. and Neitzel, J. and Menegaux, A. and Muller, Hermann and Vangkilde, S. and Finke, K. (2018) Decreased cingulo-opercular network functional connectivity mediates the impact of aging on visual processing speed. Neurobiology of Aging 73 , pp. 50-60. ISSN 0197-4580.

    [img]
    Preview
    Text
    Decreased cingulo-opercular network functional connectivity-Accepted_manuscript.pdf - Author's Accepted Manuscript

    Download (1MB) | Preview

    Abstract

    The neural factors that account for the visual processing speed reduction in aging are incompletely understood. Based on previous reports of age-related decreases in the intrinsic functional connectivity (iFC) within the cingulo-opercular network and its relevance for processing speed, we hypothesized that these decreases are associated with age-related reductions in visual processing speed. We used a whole-report task and modeling based on Bundesen's `theory of visual attention' to parameterize visual processing speed in 91 healthy participants aged from 20 to 77 years. iFC was estimated using independent component analysis of resting-state functional magnetic resonance imaging data. From the clusters within the cingulo-opercular network exhibiting age-related decreased iFC, we found a cluster in the left insula to be particularly associated with visual processing speed and to mediate the age effect on visual speed. This mediation was not observed for age-related decreased iFC in other networks or for other attentional parameters. Our results point to the iFC in the cingulo-opercular network, represented by the left insula, as being a relevant marker for visual processing speed changes in aging.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Cingulo-opercular network, Functional connectivity, Healthy aging, Processing speed, Resting-state fMRI
    School: School of Science > Psychological Sciences
    Depositing User: Hermann Muller
    Date Deposited: 21 May 2019 10:43
    Last Modified: 09 Feb 2021 22:24
    URI: https://eprints.bbk.ac.uk/id/eprint/27066

    Statistics

    Downloads
    Activity Overview
    213Downloads
    61Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item