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    Coat flexibility in the secretory pathway: a role in transport of bulky cargoes.

    Hutchings, Joshua and Zanetti, Giulia (2019) Coat flexibility in the secretory pathway: a role in transport of bulky cargoes. Current Opinion in Cell Biology 59 , pp. 104-111. ISSN 1879-0410.

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    Membrane trafficking in eukaryotic cells is a highly dynamic process, which needs to adapt to a variety of cargo proteins. The COPII coat mediates ER export of thousands of proteins with a wide range of sizes by generating coated membrane vesicles that incapsulate cargo. The process of assembly and disassembly of COPII, regulated by GTP hydrolysis, is a major determinant of the size and shape of transport carriers. Here, we analyse our knowledge of the COPII coat architecture and it assembly/disassembly dynamics, and link coat flexibility to the role of COPII in transport of large cargoes. We propose a common mechanism of action of regulatory factors that modulate COPII GTP hydrolysis cycle to promote budding.


    Item Type: Article
    School: School of Science > Biological Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Giulia Zanetti
    Date Deposited: 03 Sep 2019 12:24
    Last Modified: 14 Jun 2021 02:37


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