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    Uracil-DNA glycosylase activities in hyperthermophilic micro-organisms

    Koulis, A. and Cowan, D.A. and Pearl, L.H. and Savva, Renos (1996) Uracil-DNA glycosylase activities in hyperthermophilic micro-organisms. FEMS Microbiology Letters 143 (2-3), pp. 267-271. ISSN 0378-1097.

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    Hyperthermophiles exist in conditions which present an increased threat to the informational integrity of their DNA, particularly by hydrolytic damage. As in mesophilic organisms, specific activities must exist to restore and protect this template function of DNA. In this study we have demonstrated the presence of thermally stable uracil-DNA glycosylase activities in seven hyperthermophiles; one bacterial: Thermotoga maritima, and six archaeal: Sulfolobus solfataricus, Sulfolobus shibatae, Sulfolobus acidocaldarius, Thermococcus litoralis, Pyrococcus furiosus and Pyrobaculum islandicum. Uracil-DNA glycosylase inhibitor protein of the Bacillus subtilis bacteriophage PBS1 shows activity against all of these, suggesting a highly conserved tertiary structure between hyperthermophilic and mesophilic uracil-DNA glycosylases.


    Item Type: Article
    School: School of Science > Biological Sciences
    Research Centres and Institutes: Innovation Management Research, Birkbeck Centre for
    Depositing User: Sarah Hall
    Date Deposited: 14 May 2019 14:48
    Last Modified: 15 Oct 2019 09:03


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