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    Cockroach diuretic hormones: characterization of a calcitonin-like peptide in insects

    Furuya, K. and Milchak, R.J. and Schegg, K.M. and Zhang, J. and Tobe, S.S. and Coast, Geoffrey and Schooley, D.A. (2000) Cockroach diuretic hormones: characterization of a calcitonin-like peptide in insects. Proceedings of the National Academy of Sciences of the United States of America 97 (12), pp. 6469-6474. ISSN 0027-8424.

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    Insect diuretic hormones are crucial for control of water balance. We isolated from the cockroach Diploptera punctata two diuretic hormones (DH), Dippu-DH31 and Dippu-DH46, which increase cAMP production and fluid secretion in Malpighian tubules of several insect species. Dippu-DH31 and -DH46 contain 31 and 46 amino acids, respectively. Dippu-DH46 belongs to the corticotropin-releasing factor (CRF)-like insect DH family, whereas Dippu-DH31 has little sequence similarity to the CRF-like DH, but is similar to the calcitonin family. Dippu-DH46 and -DH31 have synergistic effects in D. punctata but have only additive effects in Locusta migratoria. Dippu-DH31 represents a distinct type of insect DH with actions that differ from those of previously identified insect peptides with diuretic activity.


    Item Type: Article
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Depositing User: Sarah Hall
    Date Deposited: 20 May 2019 15:44
    Last Modified: 02 Aug 2023 17:51


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