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    Different approaches to relating genotype to phenotype in developmental disorders

    Karmiloff-Smith, Annette and Scerif, G. and Thomas, Michael S.C. (2002) Different approaches to relating genotype to phenotype in developmental disorders. Developmental Psychobiology 40 (3), pp. 311-322. ISSN 0012-1630.

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    Discusses the complex problem of relating genotype to phenotype and challenge the simple mapping of genes to higher level cognitive modules. The authors examine various methods that have been used to investigate this relation including quantitative genetics, molecular genetics, animal models, and in-depth psychological and computational studies of developmental disorders. Both single gene and multiple gene disorders indicate that the relationship between genotype and phenotype is very indirect and that, rather than identifying mere snapshots of developmental outcomes, the process of ontogenetic development itself must be taken into account.


    Item Type: Article
    Additional Information: Under review, full-text locked until further notice
    Keyword(s) / Subject(s): Genotype-phenotype relations, developmental disorders, animal models, genetics, ontogenetic development
    School: School of Science > Psychological Sciences
    Research Centres and Institutes: Educational Neuroscience, Centre for, Birkbeck Knowledge Lab, Brain and Cognitive Development, Centre for (CBCD)
    Depositing User: Administrator
    Date Deposited: 02 Dec 2010 09:30
    Last Modified: 16 Jun 2021 06:24


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