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    Pupil-linked phasic arousal evoked by violation but not emergence of regularity within rapid sound sequences

    Zhao, S. and Chait, M. and Dick, Frederic and Dayan, P. and Furukawa, S. and Liao, H.-I. (2019) Pupil-linked phasic arousal evoked by violation but not emergence of regularity within rapid sound sequences. Nature Communications 10 (1), p. 4030. ISSN 2041-1723.

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    Abstract

    The ability to track the statistics of our surroundings is a key computational challenge. A prominent theory proposes that the brain monitors for unexpected uncertainty - events which deviate substantially from model predictions, indicating model failure. Norepinephrine is thought to play a key role in this process by serving as an interrupt signal, initiating model-resetting. However, evidence is from paradigms where participants actively monitored stimulus statistics. To determine whether Norepinephrine routinely reports the statistical structure of our surroundings, even when not behaviourally relevant, we used rapid tone-pip sequences that contained salient pattern-changes associated with abrupt structural violations vs. emergence of regular structure. Phasic pupil dilations (PDR) were monitored to assess Norepinephrine. We reveal a remarkable specificity: When not behaviourally relevant, only abrupt structural violations evoke a PDR. The results demonstrate that Norepinephrine tracks unexpected uncertainty on rapid time scales relevant to sensory signals.

    Metadata

    Item Type: Article
    School: School of Science > Psychological Sciences
    SWORD Depositor: Mr Joe Tenant
    Depositing User: Mr Joe Tenant
    Date Deposited: 09 Oct 2019 13:32
    Last Modified: 28 Jun 2020 00:24
    URI: https://eprints.bbk.ac.uk/id/eprint/29362

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