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    Investigation of depth dependent changes in cerebral haemodynamics during face perception in infants

    Blasi, A. and Fox, S. and Everdell, N. and Volein, A. and Tucker, L. and Csibra, Gergely and Gibson, A.P. and Hebden, J.C. and Johnson, M.H. and Elwell, C.E. (2007) Investigation of depth dependent changes in cerebral haemodynamics during face perception in infants. Physics in Medicine and Biology 52 (23), pp. 6849-6864. ISSN 0031-9155.

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    Abstract

    Near-infrared spectroscopy has been used to record oxygenation changes in the visual cortex of 4 month old infants. Our in-house topography system, with 30 channels and 3 different source–detector separations, recorded changes in the concentration of oxy-, deoxy- and total haemoglobin (HbO2, HHb and HbT) in response to visual stimuli (face, scrambled visual noise and cartoons as rest). The aim of this work was to demonstrate the capability of the system to spatially localize functional activation and study the possibility of depth discrimination in the haemodynamic response. The group data show both face stimulation and visual noise stimulation induced significant increases in HbO2 from rest, but the increase in HbO2 with face stimulation was not significantly different from that seen with visual noise stimulation. The face stimuli induced increases in HbO2 were spread across a greater area across all depths than visual noise induced changes. In results from a single subject there was a significant increase of HbO2 in the inferior area of the visual cortex in response to both types of stimuli, and a larger number of channels (source–detector pairs) showed HbO2 increase to face stimuli, especially at the greatest depth. Activation maps were obtained using 3D reconstruction methods on multi source–detector separation optical topography data.

    Metadata

    Item Type: Article
    School: School of Science > Psychological Sciences
    Depositing User: Sarah Hall
    Date Deposited: 15 Oct 2019 09:09
    Last Modified: 15 Oct 2019 09:09
    URI: https://eprints.bbk.ac.uk/id/eprint/29483

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