Wan, Cen and Cozzetto, D. and Fa, R. and Jones, D. (2019) Using Deep Maxout Neural Networks to improve the accuracy of function prediction from Protein Interaction Networks. PLoS One , ISSN 1932-6203.
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Abstract
Protein-protein interaction network data provides valuable information that infers direct links between genes and their biological roles. This information brings a fundamental hypothesis for protein function prediction that interacting proteins tend to have similar functions. With the help of recently-developed network embedding feature generation methods and deep maxout neural networks, it is possible to extract functional representations that encode direct links between protein-protein interactions information and protein function. Our novel method, STRING2GO, successfully adopts deep maxout neural networks to learn functional representations simultaneously encoding both protein-protein interactions and functional predictive information. The experimental results show that STRING2GO outperforms other protein-protein interaction network-based prediction methods and one benchmark method adopted in a recent large scale protein function prediction competition.
Metadata
| Item Type: | Article |
|---|---|
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Computing and Mathematical Sciences |
| Depositing User: | Cen Wan |
| Date Deposited: | 23 Oct 2019 17:46 |
| Last Modified: | 29 Jul 2025 02:28 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/29618 |
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