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    Pictet-Spenglerases in Alkaloid Biosynthesis: future applications in Biocatalysis

    Roddan, R. and Ward, J.M. and Keep, Nicholas H. and Hailes, H.C. (2020) Pictet-Spenglerases in Alkaloid Biosynthesis: future applications in Biocatalysis. Current Opinion in Chemical Biology 55 , pp. 69-76. ISSN 1367-5931.

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    Pictet-Spenglerases provide a key role in the biosynthesis of many biologically-active alkaloids. There is increasing use of these biocatalysts as an alternative to traditional organic synthetic methods as they provide stereoselective and regioselective control under mild conditions. Products from these enzymes also contain privileged drug scaffolds (such as tetrahydroisoquinoline or b-carboline moieties), so there is interest in the characterisation and use of these enzymes as versatile biocatalysts to synthesize analogues of the corresponding natural products for drug discovery. This review discusses all known Pictet- Spenglerase enzymes and their applications as biocatalysts. Rebecca , John M. , Nicholas H. and Helen C. *


    Item Type: Article
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Depositing User: Nick Keep
    Date Deposited: 19 Dec 2019 09:01
    Last Modified: 02 Aug 2023 17:56


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