An intrinsically disordered proteins community for ELIXIR.

Davey, N.E. and Babu, M.M. and Blackledge, M. and Bridge, A. and Capella-Gutierrez, S. and Dosztanyi, Z. and Drysdale, R. and Edwards, R.J. and Elofsson, A. and Felli, I.C. and Gibson, T.J. and Gutmanas, A. and Hancock, J.M. and Harrow, J. and Higgins, D. and Jeffries, C.M. and Le Mercier, P. and Mészáros, B. and Necci, M. and Notredame, C. and Orchard, S. and Ouzounis, C.A. and Pancsa, R. and Papaleo, E. and Pierattelli, R. and Piovesan, D. and Promponas, V.J. and Ruch, P. and Rustici, G. and Romero, P. and Sarntivijai, S. and Saunders, G. and Schuler, B. and Sharan, M. and Shields, D.C. and Sussman, J.L. and Tedds, J.A. and Tompa, P. and Turewicz, M. and Vondrasek, J. and Vranken, W.F. and Wallace, Bonnie A. and Wichapong, K. and Tosatto, S.C.E. (2019) An intrinsically disordered proteins community for ELIXIR. F1000Research 8 , p. 1753. ISSN 2046-1402.

Abstract

Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELIXIR framework. The goal of these developments is to drive the creation of high-quality tools and resources to support the identification, analysis and functional characterisation of IDPs. The roadmap is the result of a workshop titled "An intrinsically disordered protein user community proposal for ELIXIR" held at the University of Padua. The workshop, and further consultation with the members of the wider IDP community, identified the key priority areas for the roadmap including the development of standards for data annotation, storage and dissemination; integration of IDP data into the ELIXIR Core Data Resources; and the creation of benchmarking criteria for IDP-related software. Here, we discuss these areas of priority, how they can be implemented in cooperation with the ELIXIR platforms, and their connections to existing ELIXIR Communities and international consortia. The article provides a preliminary blueprint for an IDP Community in ELIXIR and is an appeal to identify and involve new stakeholders.

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