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    Peri-ictal changes of cortical excitability in paediatric migraine

    Jonas, A. and Reich, A.L. and Shepherd, Alex J. and Siniatchkin, M. (2007) Peri-ictal changes of cortical excitability in paediatric migraine. In: The XIII Congress of the International Headache Society, 2007, Stockholm, Sweden. (Unpublished)

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    Objective Migraine patients are characterized by an altered cortical excitability between attacks. Different studies have provided evidence for both increased and reduced cortical excitability. One possible explanation for these inconsistent conclusions is that excitability may vary between migraine attacks and different groups may have recorded excitability changes at different phases of the interval. Methods To describe excitability changes between attacks, we performed transcranial magnetic stimulation (TMS, two 2.2-Tesla MagStim-200) over the motor cortex (EMG from the m.abductor digiti minimi) and occipital cortex (phosphene thresholds, suppression of perception with stimulus onset asynchronies between 40 and 180 msec) in 9 children suffering from migraine without aura just before, just after a migraine attack and during the interval between attacks. Moreover, motion and tilt visual after-effects (MAE/TAE) were also investigated. The psychophysical and TMS parameters of migraineurs were compared with those obtained in healthy children. Results During the interval, migraine children demonstrated significantly reduced phosphene thresholds (p = 0.002) compared with healthy controls. Before an attack, a significant increase in phosphene thresholds (p = 0.049), suppression of visual perception (p = 0.009), an increase in MAE duration (p = 0.026) and a trend for an increased TAE (p = 0.089) was observed. We found no significant changes in any of the parameters of motor cortex excitability. Conclusion Although between attacks and after an attack children with migraine demonstrate increased cortical excitability, the excitability seems to normalize before a migraine attack. This normalization may represent either a protective mechanism or an abnormal decrease in excitability just before an attack.


    Item Type: Conference or Workshop Item (Paper)
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Psychological Sciences
    Depositing User: Sarah Hall
    Date Deposited: 18 Feb 2020 15:02
    Last Modified: 02 Aug 2023 17:57


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