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    Klotho and the treatment of human malignancies

    Sachdeva, A. and Gouge, Jerome and Kontovounisios, C. and Nikolaou, S. and Ashworth, A. and Lim, K. and Chong, I. (2020) Klotho and the treatment of human malignancies. Cancers 12 (1665), ISSN 2072-6694.

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    Abstract

    Klotho was first discovered as an anti-ageing protein linked to a number of age-related disease processes, including cardiovascular, renal, musculoskeletal, and neurodegenerative conditions. Emerging research has also demonstrated a potential therapeutic role for Klotho in cancer biology, which is perhaps unsurprising given that cancer and ageing share similar molecular hallmarks. In addition to functioning as a tumour suppressor in numerous solid tumours and haematological malignancies, Klotho represents a candidate therapeutic target for patients with these diseases, the majority of whom have limited treatment options. Here, we examine contemporary evidence evaluating the anti-neoplastic effects of Klotho and describe the modulation of downstream oncogenic signalling pathways, including Wnt/β-catenin, FGF, IGF1, PIK3K/AKT, TGFβ, and the Unfolded Protein Response. We also discuss possible approaches to developing therapeutic Klotho and consider technological advances that may facilitate the delivery of Klotho through gene therapy.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Klotho, cancer, colorectal cancer
    School: School of Science > Biological Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Jerome Gouge
    Date Deposited: 07 Jul 2020 12:44
    Last Modified: 08 Jul 2020 05:37
    URI: https://eprints.bbk.ac.uk/id/eprint/32460

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