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    Mechanisms of RNA recruitment by the exosome

    Malet, Hélène and Lorentzen, Esben (2011) Mechanisms of RNA recruitment by the exosome. RNA Biology 8 (3), pp. 398-403. ISSN 1547-6286.

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    Exosome-like protein complexes are essential 3'-> 5' ribonucleases involved in processing and degradation of many RNAs. They are conserved in the three domains of life and share a common architecture comprised of a ring-like core structure organized around a central channel. RNA degradation by bacterial and archaeal exosome-like complexes requires threading through this single-stranded RNA specific channel to reach the phosphorolytic active sites buried deep within the barrel-shaped complex. In contrast most eukaryotic exosomes appear to have lost phosphorolytic activity and instead rely on hydrolytic RNases for catalytic activity raising the question of the degree of conservation of RNA recruitment mechanisms between prokaryotic and eukaryotic complexes. Recent single particle electron microscopy reconstructions of apo and RNA bound yeast exosomes provide the first direct structural evidence for a channeling mechanism by a eukaryotic exosome suggesting that this mechanism is conserved between all exosome-like complexes.


    Item Type: Article
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Depositing User: Administrator
    Date Deposited: 23 May 2011 08:31
    Last Modified: 02 Aug 2023 16:54


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