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    Structural and thermodynamic analysis of the hetero-association of theophylline with aromatic drug molecules

    Andrejuk, D.D. and Hernandez Santiago, A.A. and Khomich, V.V. and Voronov, V.K. and Davies, David B. and Evstigneev, M.P. (2008) Structural and thermodynamic analysis of the hetero-association of theophylline with aromatic drug molecules. Journal of Molecular Structure 889 (1-3), pp. 229-236. ISSN 0022-2860.

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    Abstract

    The hetero-association of theophylline (THP) with other biologically-active aromatic molecules (e.g. the anti-cancer drugs daunomycin and novantrone, the antibiotic norfloxacin, the vitamin flavin-mononucleotide and two mutagens ethidium bromide and proflavine) has been studied by NMR in aqueous-salt solution (0.1 M Na-phosphate buffer, pD 7.1). It was found that THP shows an essentially similar hetero-association ability as caffeine (CAF) towards aromatic drugs, except for novantrone (NOV), which has much less affinity to THP than CAF as a result of energetically unfavourable orthogonal orientation of the chromophores of THP and NOV in the hetero-complex.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Hetero-association, Theophylline, aromatic drugs, NMR, interceptor
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Depositing User: Administrator
    Date Deposited: 29 Jul 2011 08:48
    Last Modified: 02 Aug 2023 16:55
    URI: https://eprints.bbk.ac.uk/id/eprint/3916

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