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    A C-terminal aldehyde analog of the insect kinins inhibits diuresis in the housefly

    Nachman, R.J. and Fehrentz, J.A. and Martinez, J. and Kaczmarek, K. and Zabrocki, J. and Coast, Geoffrey M. (2007) A C-terminal aldehyde analog of the insect kinins inhibits diuresis in the housefly. Peptides 28 (1), 146 - 152. ISSN 0196-9781.

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    The insect kinins are present in a wide variety of insects and function as potent diuretic peptides in flies. A C-terminal aldehyde insect kinin analog, Fmoc-RFFPWG-H (R-LK-CHO), demonstrates stimulation of Malpighian tubule fluid secretion in crickets, but shows inhibition of both in vitro and in vivo diuresis in the housefly. R-LK-CHO reduced the total amount of urine voided over 3 h from flies injected with 1 μL of distilled water by almost 50%. The analog not only inhibits stimulation of housefly fluid secretion by the native kinin Musdo-K, but also by thapsigargin, a SERCA inhibitor, and by ionomycin, a calcium ionophore. The activity of R-LK-CHO is selective, however, as related C-terminal aldehyde analogs do not demonstrate an inhibitory response on housefly fluid secretion. The selective inhibitory activity of R-LK-CHO on housefly tubules represents an important lead in the development of environmentally friendly insect management agents based on the insect kinins.


    Item Type: Article
    Keyword(s) / Subject(s): Insect kinins, pest control, musca domestica
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Depositing User: Administrator
    Date Deposited: 02 Aug 2011 10:18
    Last Modified: 02 Aug 2023 16:55


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