Shimizu, A. and Baratchian, M. and Takeuchi, Y. and Escors, D. and MacDonald, D. and Barrett, Tracey E. and Bagneris, Claire and Collins, M. and Noursadeghi, M. (2011) Kaposi's Sarcoma-Associated Herpesvirus vFLIP and Human T Cell Lymphotropic Virus Type 1 Tax Oncogenic Proteins Activate I B Kinase Subunit by Different Mechanisms Independent of the Physiological Cytokine-Induced Pathways. Journal of Virology 85 (14), pp. 7444-7448. ISSN 0022-538X.
Abstract
Activation of I{kappa}B kinase subunit {gamma} (IKK{gamma}), a key regulator of the classical NF-{kappa}B pathway, by the vFLIP protein of Kaposi's sarcoma-associated herpesvirus (KSHV) and the Tax protein of human T cell lymphotropic virus type 1 (HTLV1) is essential for virus-associated cancer. We show that vFLIP and Tax activate this pathway by different interactions with IKK{gamma} and independently of the ubiquitin-mediated signaling pathways induced by cytokines. Our data provide new insights into the mechanisms by which IKK{gamma} can be activated and show that NF-{kappa}B activation by oncogenic viruses can be targeted without affecting physiologically important pathways.
Metadata
| Item Type: | Article |
|---|---|
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences |
| Research Centres and Institutes: | Structural Molecular Biology, Institute of (ISMB) |
| Depositing User: | Administrator |
| Date Deposited: | 15 Aug 2011 15:24 |
| Last Modified: | 02 Aug 2023 16:56 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/4088 |
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