BIROn - Birkbeck Institutional Research Online

    Equivocal, explicit and emergent actions of PKC isoforms in Cancer

    Parker, P.J. and Brown, S.J. and Calleja, V. and Chakravarty, P. and Cobbaut, M. and Linch, M. and Marshall, J.J.T. and Martini, S. and McDonald, Neil Q. and Soliman, T. and Watson, L. (2020) Equivocal, explicit and emergent actions of PKC isoforms in Cancer. Nature Reviews Cancer , ISSN 1474-175X. (In Press)

    [img] Text
    41086_3_art_0_qhl0pd.pdf - Author's Accepted Manuscript
    Restricted to Repository staff only

    Download (263kB)


    The maturing mutational landscape of cancer genomes, the development and application of clinical interventions, and evolving insights into tumour- associated functions, reveal unexpected features of the protein kinase C (PKC) family of serine/threonine protein kinases. These advances include recent work showing gain or loss-of-function mutations relating to driver or bystander roles, how conformational constraints and plasticity impact this class of proteins and how emergent cancer associated properties may offer opportunities for intervention. The profound impact of the tumour microenvironment, reflected in the efficacy of immune checkpoint interventions, further prompts to incorporate PKC family actions and interventions in this eco-system, informed by insights into the control of stromal and immune cell functions. Drugging PKC isoforms has offered much promise, but the when and how is not obvious.


    Item Type: Article
    School: School of Science > Biological Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Neil McDonald
    Date Deposited: 29 Oct 2020 10:25
    Last Modified: 29 Jul 2021 18:08


    Activity Overview

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item