BIROn - Birkbeck Institutional Research Online

    Germline immunoglobulin genes: disease susceptibility genes hidden in plain sight?

    Collins, A.M. and Yaari, G. and Shepherd, Adrian J. and Lees, William and Watson, C.T. (2020) Germline immunoglobulin genes: disease susceptibility genes hidden in plain sight? Current Opinion in Systems Biology , ISSN 24523100. (In Press)

    [img]
    Preview
    Text
    CurrentOpinions_Yaari_and_Collins_submitted.pdf - Author's Accepted Manuscript
    Available under License Creative Commons Attribution Non-commercial No Derivatives.

    Download (227kB) | Preview

    Abstract

    Immunoglobulin genes are rarely considered as disease susceptibility genes despite their obvious and central contributions to immune function. This appears to be a consequence of historical views on antibody repertoire formation that no longer stand, and of difficulties that until recently surrounded the documentation of the suite of antibody genes in any individual. If these important genes are to be accessible to GWAS studies, allelic variation within the human population needs to be better documented, and a curated set of genomic variations associated with antibody genes needs to be formulated. Repertoire studies arising from the COVID-19 pandemic provide an opportunity to meet these needs, and may provide insights into the profound variability that is seen in outcomes to this infection.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): immunoglobulin, AIRR-Seq, Rep-Seq, antibody receptor repertoires, IGHV, immune receptor genes
    School: School of Science > Biological Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Adrian Shepherd
    Date Deposited: 11 Nov 2020 12:01
    Last Modified: 24 Oct 2021 00:10
    URI: https://eprints.bbk.ac.uk/id/eprint/41366

    Statistics

    Downloads
    Activity Overview
    3Downloads
    44Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item