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    Annual Research Review: Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) – a systems neuroscience approach to common developmental disorders

    Johnson, Mark H. and Charman, Tony and Pickles, Andrew and Jones, Emily J.H. (2020) Annual Research Review: Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) – a systems neuroscience approach to common developmental disorders. Journal of Child Psychology and Psychiatry , ISSN 1469-7610. (In Press)

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    Abstract

    We present the Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) framework, designed to reframe the field of prospective studies of neurodevelopmental disorders. In AMEND we propose conceptual, statistical and methodological approaches to separating markers of early-stage perturbations from later developmental modifiers. We describe the evidence for, and features of, these interacting components before outlining analytical approaches to studying how different profiles of early perturbations and later modifiers interact to produce phenotypic outcomes. We suggest this approach could both advance our theoretical understanding and clinical approach to the emergence of developmental psychopathology in early childhood.

    Metadata

    Item Type: Article
    Additional Information: This is the peer reviewed version of the article, which has been published in final form at the link above. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
    School: School of Science > Psychological Sciences
    Research Centres and Institutes: Brain and Cognitive Development, Centre for (CBCD)
    Depositing User: Emily Jones
    Date Deposited: 11 Jan 2021 07:48
    Last Modified: 16 Jun 2021 12:24
    URI: https://eprints.bbk.ac.uk/id/eprint/42032

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