BIROn - Birkbeck Institutional Research Online

    Genetic overlap and causal associations between smoking behaviours and mental health

    Barkhuizen, W. and Dudbridge, F. and Ronald, Angelica (2021) Genetic overlap and causal associations between smoking behaviours and mental health. Scientific Reports 11 (14871), ISSN 2045-2322.

    [img] Text
    Supplementary material_24May21_78050e8a-c3f1-4fbe-9b0b-417caa27663b.pdf - Supplemental Material
    Restricted to Repository staff only

    Download (5MB)
    [img] Text
    44696.pdf - Author's Accepted Manuscript
    Restricted to Repository staff only

    Download (776kB)
    44696b.pdf - Published Version of Record
    Available under License Creative Commons Attribution.

    Download (1MB) | Preview


    Cigarette smoking is a modifiable behaviour associated with mental health. We investigated the degree of genetic overlap between smoking behaviours and psychiatric traits and disorders, and whether genetic associations exist beyond genetic influences shared with confounding variables (cannabis and alcohol use, risk-taking and insomnia). Second, we investigated the presence of causal associations between smoking initiation and psychiatric traits and disorders. We found significant genetic correlations between smoking and psychiatric disorders and adult psychotic experiences. When genetic influences on known covariates were controlled for, genetic associations between most smoking behaviours and schizophrenia and depression endured (but not with bipolar disorder or most psychotic experiences). Mendelian randomization results supported a causal role of smoking initiation on psychiatric disorders and adolescent cognitive and negative psychotic experiences, although not consistently across all sensitivity analyses. In conclusion, smoking and psychiatric disorders share genetic influences that cannot be attributed to covariates such as risk-taking, insomnia or other substance use. As such, there may be some common genetic pathways underlying smoking and psychiatric disorders. In addition, smoking may play a causal role in vulnerability for mental illness.


    Item Type: Article
    School: School of Science > Psychological Sciences
    Depositing User: Angelica Ronald
    Date Deposited: 22 Jul 2021 08:11
    Last Modified: 23 Jul 2021 19:04


    Activity Overview

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item