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    Caloric vestibular stimulation modulates nociceptive evoked potentials

    Ferrè, Elisa Raffaella and Haggard, P. and Bottini, G. and Iannetti, G.D. (2015) Caloric vestibular stimulation modulates nociceptive evoked potentials. Experimental Brain Research 233 (12), pp. 3393-3401. ISSN 0014-4819.

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    Abstract

    Vestibular stimulation has been reported to alleviate central pain. Clinical and physiological studies confirm pervasive interactions between vestibular signals and somatosensory circuits, including nociception. However, the neural mechanisms underlying vestibular-induced analgesia remain unclear, and previous clinical studies cannot rule out explanations based on alternative, non-specific effects such as distraction or placebo. To investigate how vestibular inputs influence nociception, we combined caloric vestibular stimulation (CVS) with psychophysical and electrocortical responses elicited by nociceptive-specific laser stimulation in humans (laser-evoked potentials, LEPs). Cold water CVS applied to the left ear resulted in significantly lower subjective pain intensity for experimental laser pain to the left hand immediately after CVS, relative both to before CVS and to 1 h after CVS. This transient reduction in pain perception was associated with reduced amplitude of all LEP components, including the early N1 wave reflecting the first arrival of nociceptive input to primary somatosensory cortex. We conclude that cold left ear CVS elicits a modulation of both nociceptive processing and pain perception. The analgesic effect induced by CVS could be mediated either by subcortical gating of the ascending nociceptive input, or by direct modulation of the primary somatosensory cortex.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Vestibular system, Nociception, Caloric Vestibular Stimulation, Laser-evoked potentials, Analgesia, Multisensory modulation.
    School: School of Science > Psychological Sciences
    Depositing User: Elisa Raffaella Ferre
    Date Deposited: 08 Sep 2021 08:55
    Last Modified: 09 Sep 2021 18:26
    URI: https://eprints.bbk.ac.uk/id/eprint/45570

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