Mechanistic diversity in MHC class I antigen recognition
Barbosa, C.R.R. and BARTON, Justin and Shepherd, Adrian and Mishto, M. (2021) Mechanistic diversity in MHC class I antigen recognition. Biochemical Journal 478 (24), pp. 4187-4202. ISSN 0264-6021.
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Abstract
Throughout its evolution, the human immune system has developed a plethora of strategies to diversify the antigenic peptide sequences that can be targeted by the CD8+ T cell response against pathogens and aberrations of self. Here we provide a general overview of the mechanisms that lead to the diversity of antigens presented by MHC class I complexes and their recognition by CD8+ T cells, together with a more detailed analysis of recent progress in two important areas that are highly controversial: the prevalence and immunological relevance of unconventional antigen peptides; and cross-recognition of antigenic peptides by the T cell receptors of CD8+ T cells.
Metadata
| Item Type: | Article |
|---|---|
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences |
| Research Centres and Institutes: | Structural Molecular Biology, Institute of (ISMB) |
| Depositing User: | Adrian Shepherd |
| Date Deposited: | 15 Mar 2022 07:40 |
| Last Modified: | 02 Aug 2023 18:14 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/46845 |
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