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    Mechanistic diversity in MHC class I antigen recognition

    Barbosa, C.R.R. and BARTON, Justin and Shepherd, Adrian and Mishto, M. (2021) Mechanistic diversity in MHC class I antigen recognition. Biochemical Journal 478 (24), pp. 4187-4202. ISSN 0264-6021.

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    Throughout its evolution, the human immune system has developed a plethora of strategies to diversify the antigenic peptide sequences that can be targeted by the CD8+ T cell response against pathogens and aberrations of self. Here we provide a general overview of the mechanisms that lead to the diversity of antigens presented by MHC class I complexes and their recognition by CD8+ T cells, together with a more detailed analysis of recent progress in two important areas that are highly controversial: the prevalence and immunological relevance of unconventional antigen peptides; and cross-recognition of antigenic peptides by the T cell receptors of CD8+ T cells.


    Item Type: Article
    School: School of Science > Biological Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Adrian Shepherd
    Date Deposited: 15 Mar 2022 07:40
    Last Modified: 17 Mar 2022 06:09


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