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    Challenges in defining the functional, non-coding, expressed genome of members of the Mycobacterium tuberculosis complex

    Stiens, Jennifer and Arnvig, Kristine B. and Kendall, S.L. and Nobeli, Irene (2022) Challenges in defining the functional, non-coding, expressed genome of members of the Mycobacterium tuberculosis complex. Molecular Microbiology 117 (1), pp. 20-31. ISSN 0950-382X.

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    Abstract

    A definitive transcriptome atlas for the non-coding expressed elements of the members of the Mycobacterium tuberculosis complex (MTBC) does not exist. Incomplete lists of non-coding transcripts can be obtained for some of the reference genomes (e.g. Mycobacterium tuberculosis H37Rv) but to what extent these transcripts have homologues in closely related species or even strains is not clear. This has implications for the analysis of transcriptomic data; non-coding parts of the transcriptome are often ignored in the absence of formal, reliable annotation. Here, we review the state of our knowledge of non-coding RNAs in pathogenic mycobacteria, emphasising the disparities in the information included in commonly used databases. We then proceed to review ways of combining computational solutions for predicting the non-coding transcriptome with experiments that can help refine and confirm these predictions.

    Metadata

    Item Type: Article
    Additional Information: This is the peer reviewed version of the article, which has been published in final form at the link above. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
    School: School of Science > Biological Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Irene Nobeli
    Date Deposited: 27 Jan 2022 13:37
    Last Modified: 29 Jan 2022 07:23
    URI: https://eprints.bbk.ac.uk/id/eprint/47229

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