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    Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry

    Bertelsen, N. and Landi, I. and Bethlehem, R.A.I. and Seidlitz, J. and Busuoli, E.M. and Mandelli, V. and Satta, E. and Trakoshis, S. and Auyeung, B. and Kundu, P. and Loth, E. and Dumas, G. and Baumeister, S. and Beckmann, C.F. and Bölte, S. and Bourgeron, T. and Charman, T. and Durston, S. and Ecker, C. and Holt, R.J. and Johnson, Mark H. and Jones, Emily J.H. and Mason, L. and Meyer-Lindenberg, A. and Moessnang, C. and Oldehinkel, M. and Persico, A.M. and Tillmann, J. and Williams, S.C.R. and Spooren, W. and Murphy, D.G.M. and Buitelaar, J.K. and Baron-Cohen, S. and Lai, M.-C. and Lombardo, M.V. (2021) Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry. Communications Biology 4 (1), ISSN 2399-3642.

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    Abstract

    Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here, we developed a phenotypic stratification model that makes highly accurate (97–99%) out-of-sample SC = RRB, SC > RRB, and RRB > SC subtype predictions. Applying this model to resting state fMRI data from the EU-AIMS LEAP dataset (n = 509), we find that while the phenotypic subtypes share many commonalities in terms of intrinsic functional connectivity, they also show replicable differences within some networks compared to a typically-developing group (TD). Specifically, the somatomotor network is hypoconnected with perisylvian circuitry in SC > RRB and visual association circuitry in SC = RRB. The SC = RRB subtype show hyperconnectivity between medial motor and anterior salience circuitry. Genes that are highly expressed within these networks show a differential enrichment pattern with known autism-associated genes, indicating that such circuits are affected by differing autism-associated genomic mechanisms. These results suggest that SC-RRB imbalance subtypes share many commonalities, but also express subtle differences in functional neural circuitry and the genomic underpinnings behind such circuitry.

    Metadata

    Item Type: Article
    School: School of Science > Psychological Sciences
    Depositing User: Administrator
    Date Deposited: 11 Nov 2022 16:52
    Last Modified: 12 Nov 2022 05:17
    URI: https://eprints.bbk.ac.uk/id/eprint/49807

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