Smith, M.M. and LeBlanc, A. and Underwood, Charles and Johanson, Z. (2023) Odontoblast repertoire delivers significantly different dental tissues from pluripotent neural crest-derived cells. In: Chen, Donglei (ed.) Odontodes. Boca Raton, U.S.: CRC Press, pp. 142-178. ISBN 9781032065151.
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Abstract
Odontoblasts are known for depositing the dentine that comprises the internal structure of teeth and skin denticles (scales) as well as their embryonic source from cranial neural crest ectomesenchyme. Their unique cytology, including dominant single cytoplasmic processes embedded within the mineralised tissue (forming tubules), derived from their migratory character, makes them easily recognizable in adult tissues in both fossil and extant vertebrates. This allows odontoblasts to be identified as the main drivers not only of dentine formation, but also of the first-formed enameloid, not only in teeth and denticles, but also in feeding structures in the absence of teeth and of enameloid as in holocephalans. Odontoblasts are additionally critical cells in tissue repair through their migratory and invasive properties. This pluripotent repertoire makes odontoblasts unique among all mineralised tissues.
Metadata
| Item Type: | Book Section |
|---|---|
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences |
| Research Centres and Institutes: | Earth and Planetary Sciences, Institute of |
| Depositing User: | Charles Underwood |
| Date Deposited: | 27 Feb 2024 14:34 |
| Last Modified: | 07 Jul 2025 03:59 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/52474 |
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