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    Into the fold: advances in understanding aPKC membrane dynamics

    Cobbaut, M. and Parker, P.J. and McDonald, Neil Q. (2023) Into the fold: advances in understanding aPKC membrane dynamics. Biochemical Journal 480 (24), pp. 2037-2044. ISSN 0264-6021.

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    Abstract

    Atypical protein kinase Cs (aPKCs) are part of the PKC family of protein kinases and are atypical because they don’t respond to the canonical PKC activators diacylglycerol (DAG) and Ca2+. They are central to the organization of polarized cells and are deregulated in several cancers. aPKC recruitment to the plasma membrane compartment is crucial to their encounter with substrates associated with polarizing functions. However, in contrast with other PKCs, the mechanism by which atypical PKCs are recruited there has remained elusive until recently. Here, we bring aPKC into the fold, summarizing recent reports on the direct recruitment of aPKC to membranes, providing insight into seemingly discrepant findings and integrating them with existing literature.

    Metadata

    Item Type: Article
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Neil Mcdonald
    Date Deposited: 08 Jan 2024 14:42
    Last Modified: 08 Jan 2024 17:13
    URI: https://eprints.bbk.ac.uk/id/eprint/52681

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