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    Neurocognitive Endophenotypes of OCD

    Vaghi, Matilde M. (2021) Neurocognitive Endophenotypes of OCD. In: Fineberg, N.A. and Robbins, T.W. (eds.) The Neurobiology and Treatment of OCD: Accelerating Progress. Current Topics in Behavioral Neurosciences 49. Springer, pp. 97-124. ISBN 9783030753924.

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    In this chapter, I address the concept of endophenotypes for obsessive-compulsive disorder (OCD). Endophenotypes are objective and heritable quantitative traits hypothesized to be more biologically tractable than distal clinical phenotypes. This approach has been adopted to gain a better understanding of psychiatric conditions in general. It is theorized that endophenotypes will particularly assist in clarifying both the diagnostic status and aetiological origins of complex neuropsychiatric conditions such as OCD. At the cognitive level, separable constructs of relevance for OCD have been identified. The prevailing model for OCD assumes the development of abnormalities within fronto-striatal neural circuits leading to impairment of executive functions and their neuropsychological subcomponents. Here, I address whether this model can guide towards the identification of endophenotypes for this condition and discuss possible implications.


    Item Type: Book Section
    Additional Information: Publisher Copyright: © 2021, Springer Nature Switzerland AG.
    Keyword(s) / Subject(s): Endophenotype, Executive functions, Obsessive-compulsive disorder
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Psychological Sciences
    Depositing User: Matilde Vaghi
    Date Deposited: 15 Feb 2024 08:57
    Last Modified: 15 Feb 2024 08:57


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