Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition

Bandelow, B. and Baldwin, D. and Abelli, M. and Bolea-Alamanac, B. and Bourin, M. and Chamberlain, S.R. and Cinosi, E. and Davies, S. and Domschke, K. and Fineberg, N. and Grünblatt, M. and Jarema, M. and Kim, Y.-K. and Maron, E. and Masdrakis, V. and Mikova, O. and Nutt, D. and Pallanti, S. and Pini, S. and Strohle, A. and Thibaut, F. and Vaghi, Matilde M. and Won, E. and Wedekind, D. and Wichniak, A. and Woolley, J. and Zwanzger, P. and Riederer, P. (2017) Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition. World Journal of Biological Psychiatry 18 (3), pp. 162-214. ISSN 1562-2975.

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Official URL: https://doi.org/10.1080/15622975.2016.1190867

Abstract

Objective: Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers for anxiety disorders, obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD). Methods: Findings in biomarker research were reviewed by a task force of international experts in the field, consisting of members of the World Federation of Societies for Biological Psychiatry Task Force on Biological Markers and of the European College of Neuropsychopharmacology Anxiety Disorders Research Network. Results: The present article (Part II) summarises findings on potential biomarkers in neurochemistry (neurotransmitters such as serotonin, norepinephrine, dopamine or GABA, neuropeptides such as cholecystokinin, neurokinins, atrial natriuretic peptide, or oxytocin, the HPA axis, neurotrophic factors such as NGF and BDNF, immunology and CO2 hypersensitivity), neurophysiology (EEG, heart rate variability) and neurocognition. The accompanying paper (Part I) focuses on neuroimaging and genetics. Conclusions: Although at present, none of the putative biomarkers is sufficient and specific as a diagnostic tool, an abundance of high quality research has accumulated that should improve our understanding of the neurobiological causes of anxiety disorders, OCD and PTSD.

Metadata

Item Type:	Article
School:	Birkbeck Faculties and Schools > Faculty of Science > School of Psychological Sciences
Depositing User:	Matilde Vaghi
Date Deposited:	15 Feb 2024 16:47
Last Modified:	15 Feb 2024 16:47
URI:	https://eprints.bbk.ac.uk/id/eprint/53074

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