Zanetti, Giulia and Pahuja, K.B. and Studer, S. and Shim, S. and Schekman, R. (2012) COPII and the regulation of protein sorting in mammals. Nature Cell Biology 14 (1), pp. 20-28. ISSN 1465-7392.
Abstract
Secretory proteins are transported to the Golgi complex in vesicles that bud from the endoplasmic reticulum. The cytoplasmic coat protein complex II (COPII) is responsible for cargo sorting and vesicle morphogenesis. COPII was first described in Saccharomyces cerevisiae, but its basic function is conserved throughout all eukaryotes. Nevertheless, the COPII coat has adapted to the higher complexity of mammalian physiology, achieving more sophisticated levels of secretory regulation. In this review we cover aspects of mammalian COPII-mediated regulation of secretion, in particular related to the function of COPII paralogues, the spatial organization of cargo export and the role of accessory proteins.
Metadata
| Item Type: | Article |
|---|---|
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences |
| Depositing User: | Giulia Zanetti |
| Date Deposited: | 08 May 2025 15:25 |
| Last Modified: | 08 May 2025 15:25 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/55556 |
Statistics
Additional statistics are available via IRStats2.
Archive Staff Only (login required)
