BIROn - Birkbeck Institutional Research Online

    Versatile routes to marine sponge metabolites through Benzylidene Rhodanines

    Kottakota, S.K. and Benton, M. and Evangelopoulos, Dimitrios and Guzman, Juan D. and Bhakta, Sanjib and McHugh, T.D. and Gray, M. and Groundwater, P.W. and Marrs, E.C.L. and Perry, J.D. and Harburn, J.J. (2012) Versatile routes to marine sponge metabolites through Benzylidene Rhodanines. Organic Letters 14 (24), pp. 6310-6313. ISSN 1523-7060.

    Full text not available from this repository.

    Abstract

    The first total synthesis of the marine natural products Psammaplin C and Tokaradine A is described. Benzylidene rhodanines were utilized as versatile intermediates toward the synthesis of seven brominated marine sponge metabolites through the optimization of protection group strategies. Spermatinamine demonstrated good inhibition of all cancer cell lines tested, in particular the leukemia K562 and colon cancer HT29 cell lines.

    Metadata

    Item Type: Article
    School: School of Science > Biological Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 09 Jan 2013 10:54
    Last Modified: 06 Dec 2016 11:17
    URI: https://eprints.bbk.ac.uk/id/eprint/5919

    Statistics

    Downloads
    Activity Overview
    0Downloads
    133Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item