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    Versatile routes to marine sponge metabolites through Benzylidene Rhodanines

    Kottakota, S.K. and Benton, M. and Evangelopoulos, Dimitrios and Guzman, Juan D. and Bhakta, Sanjib and McHugh, T.D. and Gray, M. and Groundwater, P.W. and Marrs, E.C.L. and Perry, J.D. and Harburn, J.J. (2012) Versatile routes to marine sponge metabolites through Benzylidene Rhodanines. Organic Letters 14 (24), pp. 6310-6313. ISSN 1523-7060.

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    The first total synthesis of the marine natural products Psammaplin C and Tokaradine A is described. Benzylidene rhodanines were utilized as versatile intermediates toward the synthesis of seven brominated marine sponge metabolites through the optimization of protection group strategies. Spermatinamine demonstrated good inhibition of all cancer cell lines tested, in particular the leukemia K562 and colon cancer HT29 cell lines.


    Item Type: Article
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 09 Jan 2013 10:54
    Last Modified: 02 Aug 2023 17:01


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