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    Influence of the COMT Genotype on Working Memory and Brain Activity Changes During Development

    Dumontheil, Iroise and Roggeman, C. and Ziermans, T. and Peyrard-Janvid, M. and Matsson, H. and Kere, J. and Klingberg, T. (2011) Influence of the COMT Genotype on Working Memory and Brain Activity Changes During Development. Biological Psychiatry 70 (3), pp. 222-229. ISSN 0006-3223.

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    Background: The Valine158Methionine (Val158Met) polymorphism of the COMT gene leads to lower enzymatic activity and higher dopamine availability in Met carriers. The Met allele is associated with better performance and reduced prefrontal cortex activation during working memory (WM) tasks in adults. Dopaminergic system changes during adolescence may lead to a reduction of basal dopamine levels, potentially affecting Met allele benefits during development. Methods: We investigated the association of COMT genotype with behavioral (n = 322) and magnetic resonance imaging data (n = 81–84) collected during performance of a visuospatial WM task and potential changes in these effects during development (reflected in age × genotype interactions). Data were collected from a cross-sectional and longitudinal typically developing sample of 6- to 20-year-olds. Results: Visuospatial WM capacity exhibited an age × genotype interaction, with a benefit of the Met allele emerging after 10 years of age. There was a parallel age × genotype interaction on WM-related activation in the right inferior frontal gyrus and intraparietal sulcus (IPS), with increases in activation with age in the Val/Val group only. Main effects of COMT genotype were also observed in the IPS, with greater gray matter volumes bilaterally and greater right IPS activation in the Val/Val group compared with the Met carriers. Conclusions: These results suggest that COMT genotype effects on WM brain activity and behavior are not static during development. The full developmental picture should be considered when trying to understand the impact of genetic polymorphisms on the mature cognition of healthy adult or psychiatric populations.


    Item Type: Article
    Additional Information: NOTICE: this is the author’s version of a work that was accepted for publication in Biological Psychology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biological Psychology 70(3), August 2011,
    Keyword(s) / Subject(s): Child development, functional magnetic resonance imaging (fMRI), genetics, gray matter, voxel-based morphometry (VBM), working memory
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Psychological Sciences
    Research Centres and Institutes: Educational Neuroscience, Centre for, Brain and Cognitive Development, Centre for (CBCD)
    Depositing User: Administrator
    Date Deposited: 01 May 2013 09:50
    Last Modified: 02 Aug 2023 17:03


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