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    Protection against avian necrotic enteritis after immunisation with NetB genetic or formaldehyde toxoids

    da Costa, S.P.F. and Mot, D. and Bokori-Brown, M. and Savva, Christos G. and Basak, Ajit K. and Van Immerseel, F. and Titball, R.W. (2013) Protection against avian necrotic enteritis after immunisation with NetB genetic or formaldehyde toxoids. Vaccine 31 (37), pp. 4003-4008. ISSN 0264-410X.

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    Abstract

    NetB (necrotic enteritis toxin B) is a recently identified β-pore-forming toxin produced by Clostridium perfringens. This toxin has been shown to play a major role in avian necrotic enteritis. In recent years, a dramatic increase in necrotic enteritis has been observed, especially in countries where the use of antimicrobial growth promoters in animal feedstuffs has been banned. The aim of this work was to determine whether immunisation with a NetB toxoid would provide protection against necrotic enteritis. The immunisation of poultry with a formaldehyde NetB toxoid or with a NetB genetic toxoid (W262A) resulted in the induction of antibody responses against NetB and provided partial protection against disease.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Clostridium perfringens, NetB, Pore-forming toxin, Necrotic enteritis, Chicken, Vaccine
    School: School of Science > Biological Sciences
    Depositing User: Administrator
    Date Deposited: 30 May 2013 11:37
    Last Modified: 11 Jun 2021 17:13
    URI: https://eprints.bbk.ac.uk/id/eprint/7093

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