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    The molecular dissection of the Chaperone-Usher Pathway

    Geibel, Sebastien and Waksman, Gabriel (2014) The molecular dissection of the Chaperone-Usher Pathway. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843 (8), pp. 1559-1567. ISSN 0167-4889.

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    Secretion systems are specialized in transport of proteins, DNA or nutrients across the cell envelope of bacteria and enable them to communicate with their environment. The chaperone-usher (CU) pathway is used for assembly and secretion of a large family of long adhesive protein polymers, termed pili, and is widespread among Gram-negative pathogens [1]. Moreover, recent evidence has indicated that CU secretion systems are also involved in sporulation [2] and [3]. In this review we focus on the structural biology of the paradigmatic type 1 and P pili CU systems encoded by uropathogenic Escherichia coli (UPEC), where recent progress has provided unprecedented insights into pilus assembly and secretion mechanism. This article is part of a Special Issue entitled:Protein trafficking & Secretion.


    Item Type: Article
    Keyword(s) / Subject(s): urinary tract infection, chaperone usher pathway, type I pilus, P pilus, adhesin, chaperone, usher, donor strand complementation, donor strand exchange
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 16 Oct 2013 16:05
    Last Modified: 02 Aug 2023 17:08


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