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    Structural organisation of the type IV secretion systems

    Waksman, Gabriel and Orlova, Elena (2014) Structural organisation of the type IV secretion systems. Current Opinion in Microbiology 17 , pp. 24-31. ISSN 1369-5274.

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    Type IV secretion (T4S) systems are large dynamic nanomachines that transport DNAs and/or proteins through the membranes of bacteria. Because of their complexity and multi-protein organisation, T4S systems have been extremely challenging to study structurally. However in the past five years significant milestones have been achieved by X-ray crystallography and cryo-electron microscopy. This review describes some of the more recent advances: the structures of some of the protein components of the T4S systems and the complete core complex structure that was determined using electron microscopy.


    Item Type: Article
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 09 Dec 2013 15:59
    Last Modified: 02 Aug 2023 17:08


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