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    Structural biology of the chaperone–usher pathway of pilus biogenesis

    Waksman, Gabriel and Hultgren, S.J. (2009) Structural biology of the chaperone–usher pathway of pilus biogenesis. Nature Reviews Microbiology 7 (11), pp. 765-774. ISSN 1740-1526.

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    The chaperone-usher (CU) pathway of pilus biogenesis is the most widespread of the five pathways that assemble adhesive pili at the surface of Gram-negative bacteria. Recent progress in the study of the structural biology of the CU pathway has unravelled the molecular basis of chaperone function and elucidated the mechanisms of fibre assembly at the outer membrane, leading to a comprehensive description of each step in the biogenesis pathway. Other studies have provided the molecular basis of host recognition by CU pili. The knowledge that has been gathered about both the assembly of and host recognition by CU pili has been harnessed to design promising antibiotic compounds.


    Item Type: Article
    School: School of Science > Biological Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Sarah Hall
    Date Deposited: 20 Jan 2014 16:42
    Last Modified: 06 Dec 2016 10:46


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