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Acta Crystallographica Section D Biological Crystallography
Javed, A. and Christodoulou, John and Cabrita, L.D. and Orlova, Elena (2017) The ribosome and its role in protein folding: looking through a magnifying glass. Acta Crystallographica Section D Biological Crystallography 73 (6), pp. 509-521. ISSN 0907-4449.
Angewandte Chemie - International Edition
Baldwin, A.J. and Anthony-Cahill, S.J. and Knowles, T.P.J. and Lippens, G. and Christodoulou, John and Barker, P.D. and Dobson, C.M. (2008) Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements. Angewandte Chemie - International Edition 47 (18), pp. 3385-3387. ISSN 1433-7851.
Biochemistry
Lendel, C. and Bertoncini, C.W. and Cremades, N. and Waudby, Christopher A. and Vendruscolo, M. and Dobson, C.M. and Schenk, D. and Christodoulou, John and Toth, G. (2009) On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of α-synuclein with congo red and lacmoid. Biochemistry 48 (35), pp. 8322-8334. ISSN 0006-2960.
Chan, P.H. and Pardon, E. and Menzer, L. and de Genst, E. and Kumita, J.R. and Christodoulou, John and Saerens, D. and Brans, A. and Bouillenne, F. and Archer, D.B. and Robinson, C.V. and Muyldermans, S. and Matagne, A. and Redfield, C. and Wyns, L. and Dobson, C.M. and Demoulin, M. (2008) Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils. Biochemistry 47 (42), pp. 11041-11054. ISSN 0006-2960.
Biomolecular NMR Assignments
Nyon, Mun Peak and Kirkpatrick, J. and Cabrita, L.D. and Christodoulou, John and Gooptu, Bibek (2012) 1H, 15N and 13C backbone resonance assignments of the archetypal serpin α1-antitrypsin. Biomolecular NMR Assignments 6 (2), pp. 153-156. ISSN 1874-2718.
Biomolecular Nmr Assignments
Vuchelen, A. and O’Day, E. and de Genst, E. and Pardon, E. and Lode Wyns, L. and Dobson, C.M. and Christodoulou, John and Hsu, S.T.D. (2009) 1H, 13C and 15N assignments of a camelid nanobody directed against human α-synuclein. Biomolecular Nmr Assignments 3 (2), pp. 231-233. ISSN 1874-2718.
Hsu, S.T.D. and Cabrita, L.D. and Christodoulou, John and Dobson, C.M. (2009) H-1, N-15 and C-13 assignments of domain 5 of Dictyostelium discoideum gelation factor (ABP-120) in its native and 8M urea-denatured states. Biomolecular Nmr Assignments 3 (1), pp. 29-31. ISSN 1874-2718.
Biophysical Journal
Ahn, M. and Hagan, C.L. and Bernardo-Gancedo, A. and De Genst, E. and Newby, F.N. and Christodoulou, John and Dhulesia, A. and Dumoulin, M. and Robinson, C.V. and Dobson, C.M. and Kumita, J.R. (2016) The significance of the location of mutations for the native-state dynamics of human Lysozyme. Biophysical Journal 111 (11), pp. 2358-2367. ISSN 0006-3495.
Current Opinion in Structural Biology
Cabrita, L.D. and Dobson, C.M. and Christodoulou, John (2010) Protein folding on the ribosome. Current Opinion in Structural Biology 20 (1), pp. 33-45. ISSN 0959-440X.
Embo Journal
Roodveldt, C. and Bertoncini, C.W. and Andersson, A. and van der Goot, A.T. and Hsu, S.T.D. and Fernandez Montesinos, R. and de Jong, J. and van Ham, T.J. and Nollen, E.A. and Pozo, D. and Christodoulou, John and Dobson, C.M. (2008) Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip. Embo Journal 28 (23), pp. 3758-3770. ISSN 0261-4189.
Hfsp Journal
Huang, J.R. and Hsu, S.T.D. and Christodoulou, John and Jackson, S.E. (2008) The extremely slow-exchanging core and acid-denatured state of green fluorescent protein. Hfsp Journal 2 (6), pp. 378-387. ISSN 1955-2068.
Israel Journal of Chemistry
Cabrita, L.D. and Dobson, C.M. and Christodoulou, John (2010) Early nascent chain folding events on the ribosome. Israel Journal of Chemistry 50 (1), pp. 99-108. ISSN 0021-2148.
Journal of Bacteriology
Blombach, F. and Launay, H. and Zorraquino, V. and Swarts, D.C. and Cabrita, L.D. and Benelli, D. and Christodoulou, John and Londei, P. and van der Oost, J. (2011) An HflX-type GTPase from Sulfolobus solfataricus binds to the 50S ribosomal subunit in all nucleotide-bound states. Journal of Bacteriology 193 (11), pp. 2861-2867. ISSN 0021-9193.
Journal of Biomolecular NMR
Chan, Sammy H.S. and Waudby, Christopher A. and Cassaignau, Anais M.E. and Cabrita, Lisa D. and Christodoulou, John (2015) Increasing the sensitivity of NMR diffusion measurements by paramagnetic longitudinal relaxation enhancement, with application to ribosome–nascent chain complexes. Journal of Biomolecular NMR 63 (2), pp. 151-163. ISSN 0925-2738.
Journal of Biomolecular Structure & Dynamics
Christodoulou, John and Hsu, S.T.D. and Cabrita, L.D. and Fucini, P. and Dobson, C.M. (2009) Probing protein folding on the Ribosome by Solution State NMR Spectroscopy. Journal of Biomolecular Structure & Dynamics 26 (6), p. 94. ISSN 0739-1102.
Journal of Cellular and Molecular Medicine
Roodveldt, C. and Christodoulou, John and Dobson, C.M. (2008) Immunological features of alpha-synuclein in Parkinson's disease. Journal of Cellular and Molecular Medicine 12 (5B), pp. 1820-1829. ISSN 1582-1838.
Journal of Magnetic Resonance
Waudby, Christopher A. and Christodoulou, John (2012) An analysis of NMR sensitivity enhancements obtained using non-uniform weighted sampling, and the application to protein NMR. Journal of Magnetic Resonance 219 , pp. 46-52. ISSN 1090-7807.
Waudby, Christopher A. and Christodoulou, John (2011) GPU accelerated Monte Carlo simulation of pulsed-field gradient NMR experiments. Journal of Magnetic Resonance 211 (1), pp. 67-73. ISSN 1090-7807.
Journal of Molecular Biology
Hsu, S.T.D. and Cabrita, L.D. and Fucini, P. and Dobson, C.M. and Christodoulou, John (2009) Structure, dynamics and folding of an Immunoglobulin Domain of the Gelation Factor (ABP-120) from Dictyostelium discoideum. Journal of Molecular Biology 388 (4), pp. 865-879. ISSN 0022-2836.
Journal of the American Chemical Society
O’Brien, E.P. and Christodoulou, John and Vendruscolo, M. and Dobson, C.M. (2012) Trigger factor slows co-translational folding through kinetic trapping while sterically protecting the nascent chain from aberrant Cytosolic interactions. Journal of the American Chemical Society 134 (26), pp. 10920-10932. ISSN 0002-7863.
Waudby, Christopher A. and Mantle, M.D. and Cabrita, L.D. and Gladden, L.F. and Dobson, C.M. and Christodoulou, John (2012) Rapid Distinction of Intracellular and Extracellular Proteins Using NMR Diffusion Measurements. Journal of the American Chemical Society 134 (28), pp. 11312-11315. ISSN 0002-7863.
O’Brien, E.P. and Christodoulou, John and Vendruscolo, M. and Dobson, C.M. (2011) New scenarios of protein folding can occur on the Ribosome. Journal of the American Chemical Society 133 (3), pp. 513-526. ISSN 0002-7863.
O’Brien, E.P. and Hsu, S.T.D. and Christodoulou, John and Vendruscolo, M. and Dobson, C.M. (2010) Transient tertiary structure formation within the Ribosome Exit Port. Journal of the American Chemical Society 132 (47), pp. 16928-16937. ISSN 0002-7863.
Hsu, S.T.D. and Cabrita, L.D. and Fucini, P. and Christodoulou, John and Dobson, C.M. (2009) Probing side-chain dynamics of a ribosome-bound nascent chain using methyl NMR spectroscopy. Journal of the American Chemical Society 131 (24), pp. 8366-8367. ISSN 0002-7863.
Nature Communications
Valleix, S. and Verona, G. and Jourde-Chiche, N. and Nédelec, B. and Mangione, P.P. and Bridoux, F. and Mangé, A. and Dogan, A. and Goujon, J.-M. and Lhomme, M. and Dauteuille, C. and Chabert, M. and Porcari, R. and Waudby, Christopher and Relini, A. and Talmud, P.J. and Kovrov, O. and Olivecrona, G. and Stoppini, M. and Christodoulou, John and Hawkins, P.N. and Grateau, G. and Delpech, M. and Kontush, A. and Gillmore, J.D. and Kalopissis, A.D. and Bellotti, V. (2016) D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile. Nature Communications 7 , p. 10353. ISSN 2041-1723.
Nature Protocols
Cassaignau, A.M. and Launay, H.M. and Karyadi, M.E. and Wang, X. and Waudby, C.A. and Deckert, A. and Robertson, A.L. and Cabrita, Lisa and Christodoulou, John (2016) A strategy for co-translational folding studies of ribosome-bound nascent chain complexes using NMR spectroscopy. Nature Protocols 11 , pp. 1492-1507. ISSN 1754-2189.
Nature Structural & Molecular Biology
Cabrita, Lisa D. and Cassaignau, Anaïs M.E. and Launay, Hélène M.M. and Waudby, Christopher A. and Wlodarski, Tomasz and Camilloni, C. and Karyadi, Maria-Evangelia and Robertson, Amy L. and Wang, Xiaolin and Wentink, Anne S. and Goodsell, Luke S. and Woolhead, C.A. and Vendruscolo, M. and Dobson, C.M. and Christodoulou, John (2016) A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding. Nature Structural & Molecular Biology 23 (4), pp. 278-285. ISSN 1545-9993.
PLoS One
Temussi, P.A. and Waudby, Christopher A. and Camilloni, C. and Fitzpatrick, A.W.P. and Cabrita, L.D. and Dobson, C.M. and Vendruscolo, M. and Christodoulou, John (2013) In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-Synuclein within E. coli cells. PLoS One 8 (8), e72286. ISSN 1932-6203.
Proceedings of the National Academy of Sciences of the United States of America
Waudby, C.A. and Wlodarski, T. and Karyadi, M.-E. and Cassaignau, A.M.E. and Chan, S.H.S. and Wentink, A.S. and Schmidt-Engler, J.M. and Camilloni, C. and Vendruscolo, M. and Cabrita, L.D. and Christodoulou, John (2018) Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis. Proceedings of the National Academy of Sciences of the United States of America 115 (39), pp. 9744-9749. ISSN 0027-8424.
Deckert, Annika and Waudby, Christopher and Wlodarski, Tomasz and Wentink, Anne and Wang, Xiaolin and Kirkpatrick, John and Paton, Jack and Camilloni, C. and Kukic, P. and Dobson, C.M. and Vendruscolo, M. and Cabrita, Lisa and Christodoulou, John (2016) Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor. Proceedings of the National Academy of Sciences of the United States of America 113 (18), pp. 5012-5017. ISSN 0027-8424.
Cabrita, L.D. and Hsu, S.T.D. and Launay, H. and Dobson, C.M. and Christodoulou, John (2009) Probing ribosome-nascent chain complexes produced in vivo by NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America 106 (52), pp. 22239-22244. ISSN 0027-8424.
Progress in Nuclear Magnetic Resonance Spectroscopy
Waudby, Christopher A. and Launay, H. and Cabrita, L.D. and Christodoulou, John (2013) Protein folding on the ribosome studied using NMR spectroscopy. Progress in Nuclear Magnetic Resonance Spectroscopy 74 , pp. 57-75. ISSN 0079-6565.
Protein Science
Nyon, M.P. and Prentice, T. and Day, J. and Kirkpatrick, J. and Sivalingam, G.N. and Lévy, Géraldine R. and Haq, I. and Irving, J. and Lomas, D.A. and Christodoulou, John and Gooptu, Bibek and Thalassinos, Konstantinos (2015) An integrative approach combining ion mobility mass spectrometry, X-ray crystallography and NMR spectroscopy to study the conformational dynamics of α1-antitrypsin upon ligand binding. Protein Science 24 (8), pp. 1301-1312. ISSN 0961-8368.
Nyon, M.P. and Prentice, T. and Day, J. and Kirkpatrick, J. and Sivalingam, G.N. and Levy, G. and Haq, I. and Irving, J.A. and Lomas, D.A. and Christodoulou, John and Gooptu, Bibek and Thalassinos, Konstantinos (2015) An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1-antitrypsin upon ligand binding. Protein Science 24 (8), pp. 1301-1312. ISSN 0961-8368.
Rivers, R.C. and Kumita, J.R. and Tartaglia, G.G. and Dedmon, M.M. and Pawar, A. and Vendruscolo, M. and Dobson, C.M. and Christodoulou, John (2009) Molecular determinants of the aggregation behavior of α- and β-synuclein. Protein Science 17 (5), pp. 887-898. ISSN 0961-8368.
Rivers, R.C. and Kumita, J.R. and Tartaglia, G.G. and Dedmon, M.M. and Pawar, A. and Vendruscolo, M. and Dobson, C.M. and Christodoulou, John (2008) Molecular determinants of the aggregation behavior of alpha- and beta-synuclein. Protein Science 17 (5), pp. 887-898. ISSN 0961-8368.
Scientific Reports
Wang, X. and Kirkpatrick, J.P. and Launay, H.M.M and de Simone, A. and Häussinger, D. and Dobson, C.M. and Vendruscolo, M. and Cabrita, L.D. and Waudby, C.A. and Christodoulou, John (2019) Probing the dynamic stalk region of the ribosome using solution NMR. Scientific Reports 9 (1), p. 13528. ISSN 2045-2322.
Ahn, M. and Waudby, C.A. and Bernardo-Gancedo, A. and De Genst, E. and Dhulesia, A. and Salvatella, X. and Christodoulou, John and Dobson, C.M. and Kumita, J.R. (2017) Application of Lysine-specific labeling to detect transient interactions present during human Lysozyme Amyloid Fibril formation. Scientific Reports 7 (1), ISSN 2045-2322.
Waudby, C.A. and Ramos, A. and Cabrita, Lisa and Christodoulou, John (2016) Two-dimensional NMR lineshape analysis. Scientific Reports 6 , p. 24826. ISSN 2045-2322.
Structure
Nyon, Mun Peak and Segu, Lakshmi and Cabrita, L.D. and Lévy, Géraldine R. and Kirkpatrick, J. and Roussel, B.D. and Patschull, Anathe O.M. and Barrett, Tracey E. and Ekeowa, U.I. and Kerr, R. and Waudby, Christopher A. and Kalsheker, N. and Hill, M. and Thalassinos, Konstantinos and Lomas, D.A. and Christodoulou, John and Gooptu, Bibek (2012) Structural dynamics associated with intermediate formation in an archetypal conformational disease. Structure 20 (3), pp. 504-512. ISSN 0969-2126.
Gsponer, J. and Christodoulou, John and Cavalli, A. and Bui, J.M. and Richter, B. and Dobson, C.M. and Vendruscolo, M. (2008) A coupled equilibrium shift mechanism in Calmodulin-Mediated signal transduction. Structure 16 (5), pp. 736-746. ISSN 0969-2126.
Trends in Biochemical Sciences
Waudby, Christopher A. and Dobson, C.M. and Christodoulou, John (2019) Nature and regulation of protein folding on the ribosome. Trends in Biochemical Sciences , ISSN 0968-0004.