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    Article

    Moccia, M. and Frett, B. and Zhang, L. and Lakkaniga, R. and Briggs, D.C. and Chauhan, R. and Brescia, A. and Federico, G. and Santoro, M. and McDonald, Neil Q. and Li, H. and Carlomagno, F. (2020) Bioisosteric discovery of NPA101.3, a second generation RET/VEGFR2 inhibitor optimized for single-agent polypharmacology. Journal of Medicinal Chemistry 63 (9), pp. 4506-4516. ISSN 0022-2623.

    Yan, W. and Lakkaniga, N.R. and Gunaganti, N. and Lv, F. and Carlomagno, F. and Santoro, M. and McDonald, Neil Q. and Frett, B. and Li, H.-Y. (2018) Insights into Current Tropomyosin Receptor Kinase (TRK) inhibitors: development and clinical application. Journal of Medicinal Chemistry 62 (4), pp. 1731-1760. ISSN 0022-2623.

    Goodman, K.M. and Kjær, S. and Beuron, F. and Knowles, P.P. and Nawrotek, A. and Burns, E.M. and Purkiss, A.G. and George, R. and Santoro, M. and Morris, E.P. and McDonald, Neil Q. (2014) RET recognition of GDNF-GFRα1 ligand by a composite binding site promotes membrane-proximal self-association. Cell Reports 18 (6), pp. 1894-1904. ISSN 2211-1247.

    Carlomagno, F. and Guida, T. and Anaganti, S. and Provitera, L. and Kjaer, S. and McDonald, Neil Q. and Ryan, A.J. and Santoro, M. (2009) Identification of tyrosine 806 as a molecular determinant of RET kinase sensitivity to ZD6474. Endocrine-Related Cancer 16 (1), pp. 233-241. ISSN 1351-0088.

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