BIROn - Birkbeck Institutional Research Online

    The role of Circular Dichroism Spectroscopy in the era of integrative structural biology

    Wallace, Bonnie (2019) The role of Circular Dichroism Spectroscopy in the era of integrative structural biology. Current Opinion in Structural Biology , ISSN 0959-440X.

    [img] Text
    27405.pdf - Author's Accepted Manuscript
    Restricted to Repository staff only
    Available under License Creative Commons Attribution Non-commercial No Derivatives.

    Download (127kB) | Request a copy

    Abstract

    Circular dichroism (CD) spectroscopy has been used widely in structural biology for literally a half century, primarily to examine the secondary structure, folding and interactions of proteins in solution. With recent developments in instrumentation, it is now possible to apply CD to many additional types of sample environments, including oriented membranes, films, and dehydrated samples. In addition, developments in bioinformatics have made validated CD spectra and metadata available for novel analysis methods on additional types of samples such as membrane proteins, intrinsically disordered proteins, multiple fold types, and multicomponent, macromolecular complexes. New software has also enabled increased inter-operability of CD with other structural biology methodologies, contributing to their use in joint studies of protein structures at various levels of organization.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Circular Dichroism Spectroscopy, Bioinformatics, Tools and Resources, 3-Dimensional Structures, Protein Secondary Structures
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Depositing User: Administrator
    Date Deposited: 03 May 2019 11:53
    Last Modified: 28 Jul 2019 23:19
    URI: http://eprints.bbk.ac.uk/id/eprint/27405

    Statistics

    Downloads
    Activity Overview
    1Download
    55Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item