Wallace, Bonnie A. (2019) The role of Circular Dichroism Spectroscopy in the era of integrative structural biology. Current Opinion in Structural Biology 58 , pp. 191-196. ISSN 0959-440X.
|
Text
27405.pdf - Author's Accepted Manuscript Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (127kB) | Preview |
Abstract
Circular dichroism (CD) spectroscopy has been used widely in structural biology for literally a half century, primarily to examine the secondary structure, folding and interactions of proteins in solution. With recent developments in instrumentation, it is now possible to apply CD to many additional types of sample environments, including oriented membranes, films, and dehydrated samples. In addition, developments in bioinformatics have made validated CD spectra and metadata available for novel analysis methods on additional types of samples such as membrane proteins, intrinsically disordered proteins, multiple fold types, and multicomponent, macromolecular complexes. New software has also enabled increased inter-operability of CD with other structural biology methodologies, contributing to their use in joint studies of protein structures at various levels of organization.
Metadata
| Item Type: | Article |
|---|---|
| Keyword(s) / Subject(s): | Circular Dichroism Spectroscopy, Bioinformatics, Tools and Resources, 3-Dimensional Structures, Protein Secondary Structures |
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences |
| Depositing User: | Administrator |
| Date Deposited: | 03 May 2019 11:53 |
| Last Modified: | 02 Aug 2023 17:51 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/27405 |
Statistics
Additional statistics are available via IRStats2.
Archive Staff Only (login required)
