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    VDJbase: an adaptive immune receptor genotype and haplotype database

    Aviv, O. and Shemesh, O. and Peres, A. and Polak, P. and Shepherd, Adrian J. and Watson, C.T. and Boyd, S.D. and Collins, A.M. and Lees, William and Yaari, G. (2019) VDJbase: an adaptive immune receptor genotype and haplotype database. Nucleic Acids Research , ISSN 0305-1048.

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    Abstract

    VDJbase is a publicly available database that offers easy searching of data describing the complete sets of gene sequences (genotypes and haplotypes) inferred from adaptive immune receptor repertoire sequencing datasets. VDJbase is designed to act as a resource that will allow the scientific community to explore the genetic variability of the immunoglobulin (Ig) and T cell receptor (TR) gene loci. It can also assist in the investigation of Ig and TR-related genetic predispositions to diseases. Our database includes web-based query and online tools to assist in visualization and analysis of the genotype and haplotype data. It enables users to detect those alleles and genes that are significantly over-represented in a particular population, in terms of genotype, haplotype and gene expression. The database website can be freely accessed at https://www.vdjbase.org/, and no login is required. The data and code use creative common licenses and are freely downloadable from https://bitbucket. org/account/user/yaarilab/projects/GPHP.

    Metadata

    Item Type: Article
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Depositing User: Adrian Shepherd
    Date Deposited: 18 Oct 2019 08:36
    Last Modified: 14 Nov 2019 20:06
    URI: http://eprints.bbk.ac.uk/id/eprint/29465

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