BIROn - Birkbeck Institutional Research Online

    Friend or foe: the same fold for attack and defense

    Lukoyanova, Natalya and Saibil, Helen R. (2008) Friend or foe: the same fold for attack and defense. Trends in Immunology 29 (2), pp. 51-53. ISSN 1471-4906.

    Full text not available from this repository.

    Abstract

    Two recent crystal structures of membrane attack complex/perforin (MACPF) domains found in the complement and perforin families unexpectedly reveal that some proteins of the immune system share a common core fold with their bacterial targets. Although a relationship between MACPF proteins and the previously characterized bacterial cholesterol-dependent cytolysins (CDCs) is not detectable by sequence analysis, the MACPF structures show that eukaryotic defense and bacterial CDC attack share a common mechanism of membrane insertion and pore formation.

    Metadata

    Item Type: Article
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 04 Aug 2010 14:09
    Last Modified: 02 Aug 2023 16:49
    URI: https://eprints.bbk.ac.uk/id/eprint/1073

    Statistics

    Activity Overview
    6 month trend
    0Downloads
    6 month trend
    223Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item