Amey, J.S. and O’Reilly, Andrias O. and Burton, M.J. and Puinean, A.M. and Mellor, I.R. and Duce, I.R. and Field, L.M. and Wallace, Bonnie A. and Williamson, M.S. and Davies, T.G.E. (2015) An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids. FEBS Letters 589 (5), pp. 598-607. ISSN 0014-5793.
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Abstract
We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin. We demonstrate that this channel has most likely arisen by adaptation (gene fission or duplication) of an invertebrate ancestral mono(hetero)meric channel. This is the only identifiable voltage-gated sodium channel homologue in the aphid genome(s), and the channel’s novel selectivity filter motif (DENS instead of the usual DEKA found in other eukaryotes) may result in a loss of sodium selectivity, as indicated experimentally in mutagenised Drosophila channels.
Metadata
| Item Type: | Article |
|---|---|
| Keyword(s) / Subject(s): | Voltage-gated sodium channel, Aphid, Evolution, Tetrodotoxin |
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences |
| Research Centres and Institutes: | Bioinformatics, Bloomsbury Centre for (Closed), Structural Molecular Biology, Institute of (ISMB) |
| Depositing User: | Administrator |
| Date Deposited: | 12 Feb 2015 13:36 |
| Last Modified: | 02 Aug 2023 17:15 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/11601 |
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