Lees, William D. and Shepherd, Adrian J. (2015) Utilities for high-throughput analysis of B-cell clonal lineages. Journal of Immunology Research , p. 323506. ISSN 2314-8861.
|
Text
12648.pdf - Author's Accepted Manuscript Available under License Creative Commons Attribution. Download (12MB) | Preview |
Abstract
There are at present few tools available to assist with the determination and analysis of B-cell lineage trees from next-generation sequencing data. Here we present two utilities that support automated large-scale analysis and the creation of publication-quality results. The tools are available on the web, and are also available for download so that they can be integrated into an automated pipeline. Critically, and in contrast to previously published tools, these utilities can be used with any suitable phylogenetic inference method and with any antibody germline library, and hence are species-independent.
Metadata
| Item Type: | Article |
|---|---|
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences |
| Research Centres and Institutes: | Bioinformatics, Bloomsbury Centre for (Closed), Structural Molecular Biology, Institute of (ISMB), Data Analytics, Birkbeck Institute for |
| Depositing User: | Administrator |
| Date Deposited: | 03 Aug 2015 11:47 |
| Last Modified: | 02 Aug 2023 17:18 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/12648 |
Statistics
Additional statistics are available via IRStats2.
Archive Staff Only (login required)
