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    Utilities for high-throughput analysis of B-cell clonal lineages

    Lees, William D. and Shepherd, Adrian J. (2015) Utilities for high-throughput analysis of B-cell clonal lineages. Journal of Immunology Research , p. 323506. ISSN 2314-8861.

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    There are at present few tools available to assist with the determination and analysis of B-cell lineage trees from next-generation sequencing data. Here we present two utilities that support automated large-scale analysis and the creation of publication-quality results. The tools are available on the web, and are also available for download so that they can be integrated into an automated pipeline. Critically, and in contrast to previously published tools, these utilities can be used with any suitable phylogenetic inference method and with any antibody germline library, and hence are species-independent.


    Item Type: Article
    School: School of Science > Biological Sciences
    Research Centres and Institutes: Bioinformatics, Bloomsbury Centre for (Closed), Structural Molecular Biology, Institute of (ISMB), Data Analytics, Birkbeck Institute for
    Depositing User: Administrator
    Date Deposited: 03 Aug 2015 11:47
    Last Modified: 24 Jun 2021 04:24


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