Vale, A.M. and Green, Simon (1996) Effects of chlordiazepoxide, nicotine and d-amphetamine in the rat potentiated startle model of anxiety. Behavioural Pharmacology 7 (2), pp. 138-143. ISSN 0955-8810.
Abstract
The effects of acute administration of chlordiazepoxide (2.5 and 5.0 mg/kg, i.p.), nicotine (0.05,0.1 and 0.4 mg/kg, s.c.) and d-amphetamine (0.5 and 1.0 mg/kg, i.p.) on rat potentiated startle were investigated. Chlordiazepoxide, 2.5 and 5.0 mg/kg, attenuated potentiation of startle, indicating an anxiolytic profile, although the effect of the higher dose was less marked and was accompanied by a reduction in overall startle response, probably reflecting drug-induced sedation. Nicotine at doses of 0.05 and 0.4 mg/kg had no significant effects in this test. However, 0.1 mg/kg nicotine eliminated potentiation of startle (in two separate experiments), an action comparable to that of 2.5 mg/kg chlordiazepoxide. d-Amphetamine at doses of 0.5 and 1.0 mg/kg did not significantly influence potentiation of startle. The results suggest that nicotine has an anxiolytic profile in the potentiated startle paradigm which is not due to its psychostimalant properties.
Metadata
| Item Type: | Article |
|---|---|
| Keyword(s) / Subject(s): | Anxiolytic effect, Chlordiazepoxide, d-Amphetamine, Nicotine, Potentiated startle, Psychostimulation, Rat |
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Psychological Sciences |
| Depositing User: | Administrator |
| Date Deposited: | 16 Feb 2016 12:48 |
| Last Modified: | 02 Aug 2023 17:21 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/14346 |
Statistics
Additional statistics are available via IRStats2.
Archive Staff Only (login required)
