BIROn - Birkbeck Institutional Research Online

    Effects of chlordiazepoxide, nicotine and d-amphetamine in the rat potentiated startle model of anxiety

    Vale, A.M. and Green, Simon (1996) Effects of chlordiazepoxide, nicotine and d-amphetamine in the rat potentiated startle model of anxiety. Behavioural Pharmacology 7 (2), pp. 138-143. ISSN 0955-8810.

    Full text not available from this repository.

    Abstract

    The effects of acute administration of chlordiazepoxide (2.5 and 5.0 mg/kg, i.p.), nicotine (0.05,0.1 and 0.4 mg/kg, s.c.) and d-amphetamine (0.5 and 1.0 mg/kg, i.p.) on rat potentiated startle were investigated. Chlordiazepoxide, 2.5 and 5.0 mg/kg, attenuated potentiation of startle, indicating an anxiolytic profile, although the effect of the higher dose was less marked and was accompanied by a reduction in overall startle response, probably reflecting drug-induced sedation. Nicotine at doses of 0.05 and 0.4 mg/kg had no significant effects in this test. However, 0.1 mg/kg nicotine eliminated potentiation of startle (in two separate experiments), an action comparable to that of 2.5 mg/kg chlordiazepoxide. d-Amphetamine at doses of 0.5 and 1.0 mg/kg did not significantly influence potentiation of startle. The results suggest that nicotine has an anxiolytic profile in the potentiated startle paradigm which is not due to its psychostimalant properties.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Anxiolytic effect, Chlordiazepoxide, d-Amphetamine, Nicotine, Potentiated startle, Psychostimulation, Rat
    School: School of Science > Psychological Sciences
    Depositing User: Administrator
    Date Deposited: 16 Feb 2016 12:48
    Last Modified: 16 Feb 2016 12:48
    URI: https://eprints.bbk.ac.uk/id/eprint/14346

    Statistics

    Downloads
    Activity Overview
    0Downloads
    99Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item